AGuIX Preclinical data oncology – Archives

Rapid evaluation of novel therapeutic strategies using a 3D collagen-based tissue-like model
Front. Bioeng. Biotechnol., 2021, 9, 53.
P. Maury, E. Porcel, A. Mau, et al.

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Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform
Lab on a Chip, 2021, 21, 2495-2510.
S. Goodarzi, A. Prunet, F. Rossetti, et al.

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3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography
Frontiers in Oncology, 2021, 25, 554668.
E. Longo, L. Sancey, A. Cedola, et al.

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Quantitative tissue pharmacokinetics and EPR effect of AGuIX® nanoparticles: a multimodal imaging study in an orthotopic glioblastoma rat model and healthy macaque
Adv Healthc Mater., 2021, 1, e2100656.
V.-L. Tran, F. Lux, N. Tournier, et al.

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Radiosensitization effect of AGuIX, a gadolinium-based nanoparticle, in nonsmall cell lung cancer
Applied Materials & Interfaces, 2020, 12, 56874-56885
Y. Du, H. Sun, F. Lux Y. Xie, L. Du, C. Xu, H. Zhang, N. He, J. Wang, Y. Liu, G. Leduc, T. Doussineau, K. Ji, Q. Wang, Z. Lin, Y. Wang, Q. Liu, O. Tillement

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Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-LINAC
Cancer Nanotechnology, 2020, 11, 1-14.
H. L. Byrne, G. Le Duc, F. Lux, O. Tillement, N. M. Holmes, A. James, U. Jelen, B. Dong, G. Liney, T. L. Roberts, Z. Kundic

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Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells
J. Nanobiotechnol., 2020, 18, 129.
L. Sancey, O. Sabido, Z. He, F. Rossetti, A. Guignandon, V. Bin, J. –L. Coll, M. Cottier, F. Lux, O. Tillement, S. Constant, C. Mas, D. Boudard

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Gadolinium-based nanoparticles can overcome the radioresistance of head and neck squamous cell carcinoma through the induction of autophagy
J. Biomed. Nanotechnol., 2020, 16, 11-124.
S. Simonet, C. Rodriguez-Lafrasse, D. Beal, S. Gerbaud, C. Malesys, O. Tillement, F. Lux, H. Fayyad-Kazan, W. Rachidi, D. Ardail

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Ultrasmall theranostic gadolinium-based nanoparticles to improve high-grade rat glioma survival
J. Clin. Neurosci., 2019, 18, 31833.
S. Dufort, G. Appelboom, C. Verry, E. L. Barbier, F. Lux, E. Bräuer-Krisch, L. Sancey, S. D. Chang, M. Zhang, S. Roux, O. Tillement, G. Le Duc

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Evaluation of the theranostic properties of gadolinium-based nanoparticles for head and neck cancer
Head Neck, 2019, 41, 403-410
R. Quatre, T. Jacquet, I. Atallah, O. Tillement, F. Lux, J. –L. Coll., S. Dufort, C. –A. Righini

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Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells
Nanomedicine:NBM, 2017, 13, 2655-2660.
A. S. Wozny, M. T. Aloy, G. Alphonse, N. Magné, M. Janier, O. Tillement, F. Lux, M. Beuve, C. Rodriguez-Lafrasse

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Key clinical beam parameters for nanoparticle-mediated radiation dose amplification
Scientific Report, 2016, 6, 34040.
A. Detappe, S. Kunjachan, P. Drané, S. Kotb, M. Myronakis, D. E. Biancur, T. Ireland, M. Wagar, F. Lux, O. Tillement, R. Berbeco

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Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells
J. Nanobiotechnology, 2016, 14, 63.
L. Stefancikova, S. Lacombe, D. Salado, E. Porcel, E. Pagacova, O. Tillement, F. Lux, D. Depes, S. Kozubek, M. Falk

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Improving proton therapy by metal-containing nanoparticles : nanoscale insights
Int. J. Nanomedicine, 2016, 11, 1549-1556.
T. Schlathölter, P. Eustache, E. Porcel, D. Salado, L. Stefancikova, O. Tillement, F. Lux, P. Mowat, A. K. Biegun, M. –J. van Goethem, H. Remita, S. Lacombe

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Evaluation of a gadolinium-based nanoparticle (AGuIX) for contrast enhanced MRI of the liver in a rat model of hepatic colorectal cancer metastases at 9.4 tesla
Rofo., 2015, 187, 1108-1115.
P. Fries, D. Morr, A. Müller, F. Lux, O. Tillement, A. Massmann, R. Seidel, T. Schäfer, M. D. Mengel, G. Schneider, A. Bücker

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Gadolinium nanoparticles and contrast agent as radiation sensitizers
Phys. Med. Biol., 2015, 60, 4449-4464.
F. Taupin, M. Flaender, R. Delorme, T. Brochard, J.F. Mayol, J. Arnaud, P. Perriat, L. Sancey, F. Lux, R. F. Barth, M. Carrière, J. L. Ravanat, H. Elleaume

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Orotracheal administration of contrast agents : a new protocol for brain tumor targeting
NMR Biomed., 2015, 28, 738-746.
A. Bianchi, D. Moncelet, F. Lux, M. Plissonneau, S. Rizzitelli, E. J. Ribot, N. Tassali, V. Bouchaud, O. Tillement, P. Voisin, Y. Crémillieux

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Nebulized gadolinium-based nanoparticles : a theranostic approach for lung tumor imaging and radiosensitization
Small, 2015, 11, 215-221.
S. Dufort, A. Bianchi, M. Henry, F. Lux, G. Le Duc, V. Josserand, C. Louis, P. Perriat, Y. Crémillieux, O. Tillement, J.-L. Coll

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Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma
Nanomedicine:NBM, 2015, 11, 247-257.
I. Miladi, M. –T. Aloy, E. Armandy, P. Mowat, D. Kryza, N. Magné, O. Tillement, F. Lux, C. Billotey, M. Janier, C. Rodriguez-Lafrasse

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Cell localisation of gadolinium-based nanoparticles and related radiosensitizing efficacy in glioblastoma cells
Cancer Nanotechnology, 2014, 5, 6.
L. Stefancikova, E. Porcel, P. Eustache, S. Li, D. Salaso, S. Marco, J.-L. Guerquin-Kern, M. Réfrégiers, O. Tillement, F. Lux, S. Lacombe

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Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment
Cancer Nanotechnology, 2014, 5, 4.
G. Le Duc, S. Roux, A. Paruta-Tuarez, S. Dufort, E. Brauer, A. Marais, C. Truillet, L. Sancey, P. Perriat, F. Lux, O. Tillement

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Gadolinium-based nanoparticles to improve the hadrontherapy performances
Nanomedicine:NBM, 2014, 10, 1601-1608.
E. Porcel, O. Tillement, F. Lux, P. Mowat, N. Usami, K. Kobayashi, Y. Furusawa, C. Le Sech, S. Li, S. Lacombe

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Targeting and in vivo imaging of non-small-cell lung cancer using nebulized multimodal contrast agents
PNAS, 2014, 111, 9247-9252.
A. Bianchi, S. Dufort, F. Lux, P.-Y. Fortin, N. Tassali, O. Tillement, J. –L. Coll, Y. Crémillieux

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Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells
Nanomedicine, 2014, 10, 1751-1755.
M. Luchette H. Korideck, M. Makrigiorgos, O. Tillement, R. Berbeco

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Biodistribution of ultrasmall gadolinium-based nanoparticles as theranostic agent : Application to brain tumors
J. Biomater. Appl., 2013, 28, 385-394.
I. Miladi, G. Le Duc, D. Kryza, A. Berniard, P. Mowat, S. Roux, J. Taleb, P. Bonazza, P. Perriat, F. Lux, O. Tillement, C. Billotey, M. Janier

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Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles
Biomaterials, 2013, 34, 181-195.
W. Rima, L. Sancey, M. -T. Aloy, E. Armandy, G. B. Alcantara, T. Epicier, A. Malchère, L. Joly-Puttoz, P. Mowat, F. Lux, O. Tillement, B. Burdin, A. Rivoire, C. Boulé, I. Anselme-Bertrand, J. Pourchez, M. Cottier, S. Roux, C. Rodriguez-Lafrasse, P. Perriat

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Towards an image-guided microbeam radiation therapy using gadolinium-based nanoparticles
ACS Nano, 2011, 5, 9566-9574.
G. Le Duc, I. Miladi, C. Alric, P. Mowat, E. Bräuer-Krisch, A. Bouchet, E. Khalil, C. Billotey, M. Janier, F. Lux, P. Perriat, S. Roux, O. Tillement

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In vitro radiosensitizing effects of ultrasmall gadolinium based particles on tumour cells
J. Nanosci. Nanotechnol., 2011, 11, 7833-7839.
P. Mowat, A. Mignot, W. Rima, F. Lux, O. Tillement, C. Roulin, M. Dutreix, D. Bechet, S. Huger, L. Humbert, M. Barberi-Heyob, M.T. Aloy, E. Armandy, C. Rodriguez-Lafrasse, G. Le Duc, S. Roux, P. Perriat

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