Pharmaceuticals (Basel). 2021 Apr 22;14(5):396. doi: 10.3390/ph14050396.
J.Daouk, M.Iltis, B.Dhaini, et al.
J.Daouk, M.Iltis, B.Dhaini, et al.
Archives Publications
Imaging and Characterization of Sustained Gadolinium Nanoparticle Release from Next Generation Radiotherapy Biomaterial
Nanomaterials (Basel). 2020 Nov 13;10(11):2249. doi: 10.3390/nano10112249.
R.Mueller, M.Moreau, S.Yasmin-Karim et al.
R.Mueller, M.Moreau, S.Yasmin-Karim et al.
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Transl Oncol. 2020 Nov;13(11):100839. doi: 10.1016/j.tranon.2020.100839. Epub 2020 Aug 4.
W.Liu, J.Deacon, H.Yan, et al.
Multiscale Selectivity and in vivo Biodistribution of NRP-1 – Targeted Theranostic AGuIX Nanoparticles for PDT of Glioblastoma
Int J Nanomedicine. 2020 Nov 9;15:8739-8758. doi: 10.2147/IJN.S261352. eCollection 2020.
M.Gries, N.Thomas, J.Daouk, et al.
M.Gries, N.Thomas, J.Daouk, et al.
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
Phys Med Biol. 2020 Oct 22;65(21):21RM02. doi: 10.1088/1361-6560/ab9159.
J.Schuemann, A.Bagley, R.Berbeco, et al.
J.Schuemann, A.Bagley, R.Berbeco, et al.
Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac
Cancer Nano 11. 2020 Oct 06; doi: 10.1186/s12645-020-00065-5.
H.L.Byrne, G.Le Duc, F.Lux, et al.
H.L.Byrne, G.Le Duc, F.Lux, et al.
Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells
J Nanobiotechnology. 2020 Sep 10;18(1):129. doi: 10.1186/s12951-020-00683-6.
L.Sancey, O.Sabido, Z.He, et al.
L.Sancey, O.Sabido, Z.He, et al.
Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy
Nanomaterials (Basel). 2020 Jul 9;10(7):1341. doi: 10.3390/nano10071341.
F.Tamanoi, K.Matsumoto, T.Le Hoang Doan, et al.
F.Tamanoi, K.Matsumoto, T.Le Hoang Doan, et al.
Anti-MUC1- C Antibody – conjugated nanoparticles potentiate the efficacy of fractionated radiation therapy
Int. J. Radiat. Oncol. Biol. Phys., 2020, 20, 6223.
A. Detappe, C. Mathieu, C. Jin, et al.
Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective
Science Advances, 2020, 6, eaay5279.
C. Verry, S. Dufort, B. Lemasson, et al.
EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: from animal to human with theranostic AGuIX® nanoparticles
Theranostics, 2020, 10, 1319-1331.
G. Bort, F. Lux, S. Dufort, et al.
Radiobiological Implications of Nanoparticles Following Radiation Treatment
Part Part Syst Charact. 2020 Apr;37(4):1900411. doi: 10.1002/ppsc.201900411. Epub 2020 Mar 3.
R.Ahmad, G.Schettino, G.Royle, et al.
R.Ahmad, G.Schettino, G.Royle, et al.
Study of the intracellular nanoparticle-based radiosensitization mechanisms in F98 glioma cells treated with charged particle therapy through synchrotron-based infrared microspectroscopy
Analyst. 2020 Mar 16;145(6):2345-2356. doi: 10.1039/c9an02350j.
I.Martínez-Rovira, O.Seksek, I.Dokic , et al.
I.Martínez-Rovira, O.Seksek, I.Dokic , et al.
Gadolinium-Based Nanoparticles Can Overcome the Radioresistance of Head and Neck Squamous Cell Carcinoma Through the Induction of Autophagy
J Biomed Nanotechnol. 2020 Jan 1;16(1):111-124. doi: 10.1166/jbn.2020.2871.
S.Simonet, C.Rodriguez-Lafrasse, D.Beal,, et al.
S.Simonet, C.Rodriguez-Lafrasse, D.Beal,, et al.
Use of nanoparticles as radiosensitizing agents in radiotherapy: State of play
Cancer Radiother. 2019 Dec;23(8):917-921. doi: 10.1016/j.canrad.2019.07.134. Epub 2019 Sep 17.
C.Verry, E.Porcel, C.Chargari, et al.
C.Verry, E.Porcel, C.Chargari, et al.
Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier
Contrast Media Mol Imaging. 2019 Dec 1;2019:6341545. doi: 10.1155/2019/6341545. eCollection 2019.
A.Conti, R.Magnin, M.Gerstenmayer, et al.
A.Conti, R.Magnin, M.Gerstenmayer, et al.
Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma
Front Bioeng Biotechnol. 2019 Nov 27;7:368. doi: 10.3389/fbioe.2019.00368. eCollection 2019.
P.Hu, Z.Fu, G.Liu, et al.
P.Hu, Z.Fu, G.Liu, et al.
Synchrotron-based infrared microspectroscopy study on the radiosensitization effects of Gd nanoparticles at megavoltage radiation energies
Analyst. 2019 Sep 9;144(18):5511-5520. doi: 10.1039/c9an00792j.
I.Martínez-Rovira, O.Seksek, J.Puxeu, et al.
I.Martínez-Rovira, O.Seksek, J.Puxeu, et al.
Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase I study protocol
BMJ Open, 2019, 9, e023591.
C. Verry, L. Sancey, S. Dufort, et al.
In vivo gadolinium nanoparticle quantification with SPECT/CT
EJNMMI Phys. 2019 Jun 18;6(1):9. doi: 10.1186/s40658-019-0246-y.
O.Kochebina, A.Halty, J.Taleb, et al.
O.Kochebina, A.Halty, J.Taleb, et al.
Multimodal AGuIX® Nanoparticles: Size Characterization by HF5 and Optimization of the Radiolabeling with Various SPECT/PET/Theranostic Tracers
Int J Med Nano Res. 2019 Feb 25.doi: 10.23937/2378-3664.1410027.
S.Huclier-Markai, E.Ntsiba, E.Thomas, et al.
S.Huclier-Markai, E.Ntsiba, E.Thomas, et al.
Recommendations for clinical translation of nanoparticle-enhanced radiotherapy
Br J Radiol. 2018 Dec;91(1092):20180325. doi: 10.1259/bjr.20180325. Epub 2018 Sep 17.
K.Ricketts, R.Ahmad, L.Beaton, et al.
K.Ricketts, R.Ahmad, L.Beaton, et al.
Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging
Contrast Media Mol Imaging. 2018 Nov 1;2018:7938267. doi: 10.1155/2018/7938267. eCollection 2018.
VL.Tran, V.Thakare, M.Natuzzi, et al.
VL.Tran, V.Thakare, M.Natuzzi, et al.
One-pot direct synthesis for multifunctional hybrid silica nanoparticles
J. Mat. Chem. B, 2018, 6, 4821-4834.
V. –L. Tran, V. Thakare, F. Rossetti, et al.
AGuIX® from bench to bedside – Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine
Br. J. Radiology, 2018, 91, 20180365.
F. Lux, V.-L. Tran, E. Thomas, et al.
Nanoparticle radio-enhancement: principles, progress and application to cancer treatment
Phys Med Biol. 2018 Jan 9;63(2):02TR01. doi: 10.1088/1361-6560/aa99ce.
Z.Kuncic, S.Lacombe
Z.Kuncic, S.Lacombe
Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy-enhancement
Med Phys. 2017 Nov;44(11):5949-5960. doi: 10.1002/mp.12570. Epub 2017 Oct 11.
R.Delorme, F.Taupin, M.Flaender, et al.
R.Delorme, F.Taupin, M.Flaender, et al.
Evaluation of Novel 64Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nude Mice
Nanoscale Res Lett. 2017 Sep 6;12(1):523. doi: 10.1186/s11671-017-2292-5.
P.Hu, D.Cheng, T.Huang, et al.
P.Hu, D.Cheng, T.Huang, et al.
68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy
Nanomedicine (Lond). 2017 Jul;12(13):1561-1574. doi: 10.2217/nnm-2017-0032.
P.Bouziotis, D.Stellas, E.Thomas, et al.
P.Bouziotis, D.Stellas, E.Thomas, et al.
Ultrasmall silica-based bismuth gadolinium nanoparticle for dual MR-CT guided radiation therapy
Nano Lett., 2017, 17, 1733-1740.
A. Detappe, E. Thomas, M. W. Tibbit, et al.
Heterogeneous intratumoral distribution of gadolinium nanoparticles within U87 human glioblastoma xenografts unveiled by micro-PIXE imaging
Anal Biochem. 2017 Apr 15;523:50-57. doi: 10.1016/j.ab.2017.02.010. Epub 2017 Feb 20.
A.Carmona, S.Roudeau, B.L’Homel, et al.
A.Carmona, S.Roudeau, B.L’Homel, et al.
3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy
Sci Rep. 2016 Jul 20;6:29936. doi: 10.1038/srep29936.
Y.Gimenez, B.Busser, F.Trichard, et al.
Y.Gimenez, B.Busser, F.Trichard, et al.
Synthesis and characterization of 89Zr-labeled ultrasmall nanoparticles
Mol. Pharm., 2016, 13, 2596-2601.
C. Truillet, E. Thomas, F. Lux, et al.
Safety evaluation and imaging properties of gadolinium based nanoparticles in nonhuman primates
Scientific Report, 2016, 6, 35053.
S. Kotb, J. Piraquive, F. Lamberton, et al.
Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy
J. Control. Release, 2016, 238, 103-113.
A. Detappe, S. Kunjachan, L. Sancey, et al.
Gadolinium-based nanoparticles and radiation therapy for multiple brain melanoma metastases : Proof of concept before phase I trial
Theranostics, 2016, 6, 418-427.
S. Kotb, A. Detappe, F. Lux, et al.
The high radiosensitizing efficiency of a trace of gadolinium-based nanoparticles in the tumor
Sci. Rep., 2016, 6, 29678.
S. Dufort, G. Le Duc, M. Salomé, et al.
MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection
Nanomedicine, 2016, 11, 2405-2417.
C. Verry, S. Dufort, E. L. Barbier, et al.
Study of the biochemical effects induced by X-ray irradiations in combination with gadolinium nanoparticles in F98 glioma cells: first FTIR studies at the Emira laboratory of the SESAME synchrotron
Analyst. 2016 Apr 7;141(7):2238-49. doi: 10.1039/c5an02378e. Epub 2016 Mar 2.
I.Yousef, O.Seksek, S.Gil, et al.
An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors
Sci Rep. 2016 Feb 19;6:21417. doi: 10.1038/srep21417.
A.Karageorgis, S.Dufort, L.Sancey, et al.
Long-Term in vivo clearance of Gadolinium-Based AGuIX (Activation and Guiding of Irradiation by X-Ray) Nanoparticles and their Biocompatibility after Systemic Injection
ACS Nano, 2015, 9, 2477-2488.
L. Sancey, S. Kotb, C. Truillet, et al.
AGuIX nanoparticles as a promising platform for image-guided radiation therapy
Cancer Nanotechnol. 2015;6(1):4. doi: 10.1186/s12645-015-0012-3. Epub 2015 Sep 2.
A.Detappe, S.Kunjachan, J.Rottmann, et al.
The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy
Br. J. Radiology, 2014, 87, 20140134.
L. Sancey, F. Lux, S. Kotb, et al.
Paramagnetic nanoparticles to track and quantify in vivo immune human therapeutic cells
Nanoscale. 2013 Dec 7;5(23):11409-15. doi: 10.1039/c3nr34240a
C.Aspord, D.Laurin, M.FJanier, et al.
Contrast enhanced lung MRI in mice using ultra-short echo time radial imaging and intratracheally administrated Gd-DOTA-based nanoparticles
Magn Reson Med. 2013 Nov;70(5):1419-26.doi: 10.1002/mrm.24580. Epub 2012 Dec 11.
A.Bianchi, F.Lux, O.Tillement, et al.
A.Bianchi, F.Lux, O.Tillement, et al.
A top-down synthesis route to ultrasmall multifunctionnal Gd-based nanoparticles for theranostic applications
Chem. Eur. J., 2013, 19, 6122-6136.
A. Mignot, C. Truillet, F. Lux, et al.
Ultrasmall Rigid Platforms as multimodal probes for medical applications
Angew. Chem. Int. Ed., 2011, 51, 12299-13303.
F. Lux, A. Mignot, P. Mowat, et al.
Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging
J Am Chem Soc. 2007 Apr 25;129(16):5076-84. doi: 10.1021/ja068356j. Epub 2007 Mar 31.
JL.Bridot, AC.Faure, S.Laurent, et al.