Pharmaceuticals. 2024 Aug 5. doi: 10.3390/ph17081033.
B.Dhaini, P.Arnoux, J.Daouk, et al.
Archives Publications
GBM trial of AGuIX nanoparticles with radiotherapy and temozolomide in the treatment of newly diagnosed Glioblastoma: Phase 1b outcomes and MRI-based biodistribution
Clinical and Translational Radiation Oncology. 2024 Jul 31. doi: 10.1016/j.ctro.2024.100833.
J.Biau, X.Durando, F.Boux, et al.
Quantifying gadolinium-based nanoparticle uptake distributions in brain metastases via magnetic resonance imaging
Scientific Reports, 2024 May 25. Article number: 11959 (2024).
S.Bennett, C.Verry, E.Kaza, et al.
Nanotechnology-based delivery systems to overcome drug resistance in cancer
Immunologie. 2024 Jan 15. doi: 10.1101/2024.01.12.575217.
Z.Muradova, D.Tannous, A.Mostefa-Kara, et al.
Gadolinium-based nanoparticles AGuIX and their combination with ionizing radiation trigger AMPK-dependent proinflammatory reprogramming of tumor-associated macrophages
Immunologie. 2024 Jan 15. doi: 10.1101/2024.01.12.575217.
Z.Muradova, D.Tannous, A.Mostefa-Kara, et al.
AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors
Nanoscale. 2024 Feb 1;16(5):2347-2360. doi: 10.1039/d3nr04777f.
L.Carmès, G.Bort, F.Lux, et al.
Biological modeling of gadolinium-based nanoparticles radio-enhancement for kilovoltage photons: a Monte Carlo study
Cancer Nanotechnology. 2023 May 2. doi: 10.1186/s12645-023-00202-w
J.Wu, X.Xu, Y.Liang, et al.
Radiation therapy-activated nanoparticle and immunotherapy: The next milestone in oncology?
Int Rev Cell Mol Biol. 2023:378:157-200. doi: 10.1016/bs.ircmb.2023.03.005. Epub 2023 Apr 21.
S.Penninckx, J.Thariat, C.Mirjolet
Gadolinium-Based Nanoparticles Sensitize Ovarian Peritoneal Carcinomatosis to Targeted Radionuclide Therapy
J Nucl Med. 2023 Dec 1;64(12):1956-1964. doi: 10.2967/jnumed.123.265418.
C.Diaz Garcia-Prada, L.Carmès, S.Atis, et al.
Toward Clinical Transfer of Tumor-Targeted Ultrasmall Inorganic Nanoparticles
Advanced therapeutics.2023 May 13;. doi: 10.1002/adtp.202300019
L.Carmès, M.Banerjee, P.Coliat, et al.
Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification
Theranostics. 2023 Aug 21;13(14):4711-4729. doi: 10.7150/thno.85663. eCollection 2023.
N.Brown, P.Rocchi, L.Carmès, et al.
Radiotherapy reimagined: Integrating nanomedicines into radiotherapy clinical trials
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 May-Jun;15(3):e1867. doi: 10.1002/wnan.1867. Epub 2022 Oct 28.
A.DuRoss, J.Phan, A.Lazar, et al.
A.DuRoss, J.Phan, A.Lazar, et al.
Clinical transfer of AGuIX®-based radiation treatments for locally advanced cervical cancer: MR quantification and in vitro insights in the NANOCOL clinical trial framework
Nanomedicine. 2023 Apr 20;50:102676. doi: 10.1016/j.nano.2023.102676. Online ahead of print.
P.Maury, M.Mondini, C.Chargari, et al.
P.Maury, M.Mondini, C.Chargari, et al.
Phase I/II study testing the combination of AGuIX nanoparticles with radiochemotherapy and concomitant temozolomide in patients with newly diagnosed glioblastoma (NANO-GBM trial protocol)
BMC Cancer. 2023 Apr 15;23(1):344. doi: 10.1186/s12885-023-10829-y.
E.Thivat, M.Casile, J.Moreau, et al.
E.Thivat, M.Casile, J.Moreau, et al.
Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX®-Design Nanoparticles
Pharmaceutics. 2023 Mar 20;15(3):997. doi: 10.3390/pharmaceutics15030997.
L.Lerouge, M.Gries, A.Chateau, et al.
L.Lerouge, M.Gries, A.Chateau, et al.
Polymeric Metal Contrast Agents for T1-Weighted Magnetic Resonance Imaging of the Brain
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1224-1242. doi: 10.1021/acsbiomaterials.2c01386. Epub 2023 Feb 8.
D.Foster, J.Larsen
D.Foster, J.Larsen
Prospects of Nanoparticle-based Radioenhancement for Radiotherapy
Recent Advances in Metal-Based NanoEnhancers for Particle Therapy
Nanomaterials (Basel). 2023 Mar 10;13(6):1011. doi: 10.3390/nano13061011.
YC.Chuang, PH.Wu, YA.Shen, et al.
YC.Chuang, PH.Wu, YA.Shen, et al.
Added Value of Scintillating Element in Cerenkov-Induced Photodynamic Therapy
Pharmaceuticals. 2023 Jan 18;16(2), 143. doi: 10.3390/ph16020143.
P.Schneller, C.Collet, Q.Been, et al.
P.Schneller, C.Collet, Q.Been, et al.
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation
Chem Soc Rev. 2023 Jan 3;52(1):47-96. doi: 10.1039/d2cs00437b.
H-Li, Q-Luo, H-Zhang, et al.
H-Li, Q-Luo, H-Zhang, et al.
Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma
Int J Nanomedicine. 2022 Dec 23;17:6655-6673. doi: 10.2147/IJN.S390056. eCollection 2022.
MT.Aloy, J.Sidi Boumedine, A.Deville, et al.
MT.Aloy, J.Sidi Boumedine, A.Deville, et al.
Gadolinium-based ultra-small nanoparticles augment radiotherapy-induced T-cell response to synergize with checkpoint blockade immunotherapy
Nanoscale. 2022 Aug 11;14(31):11429-11442. doi: 10.1039/d2nr02620a. PMID: 35904053
H.Song, H.Sun, N.He, et al.
AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway
J Nanobiotechnology. 2022 Oct 14;20(1):449. doi: 10.1186/s12951-022-01654-9.PMID: 36242003 Free PMC article.
H.Sun, H.Cai, C.Xu, et al.
T1 Mapping From MPRAGE Acquisitions: Application to the Measurement of the Concentration of Nanoparticles in Tumors for Theranostic Use
J Magn Reson Imaging. 2022 Oct 31. doi: 10.1002/jmri.28509
A. Lavielle, F. Boux, J. Deborne, et al.
Nanoparticles for MRI-guided radiation therapy: a review
Cancer Nano 13. 2022 Nov 12; doi: 10.1186/s12645-022-00145-8.
L.Smith, H.Byrne, D.Waddington, et al.
L.Smith, H.Byrne, D.Waddington, et al.
An overview of the intracellular localization of high-Z nanoradiosensitizers
Prog Biophys Mol Biol. 2022 Nov;175:14-30. doi: 10.1016/j.pbiomolbio.2022.08.006. Epub 2022 Aug 24.
M.Varzandeh, S.Labbaf, J.Varshosaz, et al.
M.Varzandeh, S.Labbaf, J.Varshosaz, et al.
Anticancer Nanotherapeutics in Clinical Trials: The Work behind Clinical Translation of Nanomedicine
Int J Mol Sci. 2022 Nov 2;23(21):13368. doi: 10.3390/ijms232113368.
A.Parodi, E.Kolesova, Maya.Voronina, et al.
A.Parodi, E.Kolesova, Maya.Voronina, et al.
Importance of Rose Bengal Loaded with Nanoparticles for Anti-Cancer Photodynamic Therapy
Pharmaceuticals (Basel). 2022 Aug 31;15(9):1093. doi: 10.3390/ph15091093.
B.Dhaini, L.Wagner, M.Moinard, et al.
B.Dhaini, L.Wagner, M.Moinard, et al.
Identification of Molecular Fragments in Equilibrium with Polysiloxane Ultrasmall Nanoparticles
Nanomaterials, 2022, 12(5), 738.
P. Rocchi, L. Labied, T. Doussineau, et al.
A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers
Pharmaceutics, 2022, 14(4), 814.
P. Rocchi, D. Brichart-Vernos, F. Lux, et al.
Research progress on nano-sensitizers for enhancing the effects of radiotherapy
Anti-BCMA Immuno-NanoPET Radiotracers for Improved Detection of Multiple Myeloma
Adv Healthc Mater. 2022 Jan;11(2):e2101565. doi: 10.1002/adhm.202101565. Epub 2021 Nov 7.
E.Thomas, C.Mathieu, P.Moreno-Gaona, et al.
E.Thomas, C.Mathieu, P.Moreno-Gaona, et al.
Gadolinium-Based Nanoparticles Combined With Checkpoint Blockade Amplify Radiation-Induced Abscopal Effect And Cancer Immunotherapy
Research Square. 2021 Dec 20; doi:10.21203/rs.3.rs-1165183/v1
H.Song , N.He, C.Xu , et al.
Microdosimetric Investigation and a Novel Model of Radiosensitization in the Presence of Metallic Nanoparticles
Pharmaceutics. 2021 Dec 18;13(12):2191. doi: 10.3390/pharmaceutics13122191.
H.Yan, D.Carlson, R.Abolfath, et al.
H.Yan, D.Carlson, R.Abolfath, et al.
Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer
ACS Appl Mater Interfaces, 2020, 12, 51, 56874-56885.
Y. Du, H. Sun, F. Lux, et al.
Biodegradation of metal-based ultra-small nanoparticles: A combined approach using TDA-ICP-MS and CE-ICP-MS
Analytica Chimica Acta, 2021.
L. Labied, P. Rocchi, T. Doussineau, et al.
Radiation nanosensitizers in cancer therapy-From preclinical discoveries to the outcomes of early clinical trials
Bioeng Transl Med. 2021 Sep 23;7(1):e10256. doi: 10.1002/btm2.10256. eCollection 2022 Jan.
C.Bilynsky, N.Millot, AL.Papa
C.Bilynsky, N.Millot, AL.Papa
Quantitative tissue pharmacokinetics and EPR effect of AGuIX® nanoparticles: a multimodal imaging study in an orthotopic glioblastoma rat model and healthy macaque
Adv Healthc Mater., 2021, 1, e2100656.
V.-L. Tran, F. Lux, N. Tournier, et al.
Multimodal imaging Gd-nanoparticles functioalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting
Nanomedicine, 2017, 12, 1675-1687.
J. Pansieri, M. Plissonneau, N. Stransky-Heilkron, et al.
Proton MR spectroscopy and diffusion MR imaging to predict tumor response to interstitial photodynamic therapy for glioblastoma
Theranostics, 2017, 7, 436-451.
M. Toussaint, S. Pinel, F. Auger, et al.
Ultrasmall AGuIX theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of glioblastoma
Int. J. Nanomedicine, 2017, 12, 7075-7088.
E. Thomas, L. Colombeau, M. Gries, et al.
Magnetic resonance lymphography at 9.4 T using a gadolinium-based nanoparticle in rat: investigations in healthy animals and a hindlimb lymphedema model
Invest. Radiol., 2017, 52, 725-733.
A. Müller, P. Fries, B. Jelvani, et al.
Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells
Nanomedicine: NBM, 2017, 13, 2655-2660.
A. S. Wozny, M. T. Aloy, G. Alphonse, et al.
Magnetic nanoparticles applications for amyloidosis study and detection: a review
Nanomaterials, 2018, 8, 0740.
J. Pansieri, M. Gerstenmeyer, F. Lux, et al.
Ultrasmall theranostic gadolinium-based nanoparticles to improve high-grade rat glioma survival
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging
RSC Advances, 2019, 9, 24811-24815.
V. Thakare, V.-L. Tran, M. Natuzzi, et al.
Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma
Nanoscale, 2019, 11, 20485-20496.
A. Detappe, M. Reidy, Y. Yu, et al.
Evaluation of the theranostic properties of gadolinium-based nanoparticles for head and neck cancer
Head Neck, 2019, 41, 403-410.
R. Quatre, T. Jacquet, I. Atallah, et al.
Gd-nanoparticles functionnalization with specific peptides for β-amyloid plaques targeting
Nanobiotechnology, 2016, 14, 60.
M. Plissonneau, J. Pansieri, L. Heinrich-Balard, et al.
Chemical and in vitro characterizations of a promising bimodal AGuIX probe able to target apoptotic cells for applications in MRI and optical imaging
Contrast Media Mol. Imaging, 2016, 11, 381-395.
M. Dentamaro, F. Lux, L. Vander Elst, et al.
MR imaging, targeting and characterization of pulmonary fibrosis using intra-tracheal administration of gadolinium-based nanoparticles
Contrast Media Mol. Imaging, 2016, 11, 396-404.
N. Tassali, A. Bianchi, F. Lux, et al.
Key clinical beam parameters for nanoparticle-mediated radiation dose amplification
Scientific Report, 2016, 6, 34040.
A. Detappe, S. Kunjachan, P. Drané, et al.
Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells
J. Nanobiotechnology, 2016, 14, 63.
L. Stefancikova, S. Lacombe, D. Salado, et al.
Improving proton therapy by metal-containing nanoparticles : nanoscale insights
Int. J. Nanomedicine, 2016, 11, 1549-1556.
T. Schlathölter, P. Eustache, E. Porcel, et al.
Pushing radiation therapy limitations with theranostic nanoparticles
Nanomedicine, 2016, 11, 997-999.
A. Detappe, F. Lux, O. Tillement.
Multifunctionnal ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI
Nanomedicine: NBM, 2015, 11, 657-670.
D. Bechet, F. Auger, P. Couleaud, et al.
Ultrasmall nanoplatforms as calcium-responsive contrast agents for magnetic resonance imaging
Small, 2015, 11, 4900-4909.
A. Moussaron, S. Vibhute, A. Bianchi, et al.
Ultrasmall particles for Gd-MRI and 68Ga-PET dual imaging
Contrast Media Mol. Imaging, 2015, 10, 309-319.
C. Truillet, P. Bouziotis, C. Tsoukalas, et al.
Combining ultrasmall gadolinium-based nanoparticles with photon irradiation overcomes radioresistance of head and neck squamous cell carcinoma
Nanomedicine: NBM, 2015, 11, 247-257.
I. Miladi, M.-T. Aloy, E. Armandy, et al.
Nebulized gadolinium-based nanoparticles : a theranostic approach for lung tumor imaging and radiosensitization
Small, 2015, 11, 215-221.
S. Dufort, A. Bianchi, M. Henry, et al.
Orotracheal administration of contrast agents: a new protocol for brain tumor targeting
NMR Biomed., 2015, 28, 738-746.
A. Bianchi, D. Moncelet, F. Lux, et al.
Gadolinium nanoparticles and contrast agent as radiation sensitizers
Phys. Med. Biol., 2015, 60, 4449-4464.
F. Taupin, M. Flaender, R. Delorme, et al.
Evaluation of a gadolinium-based nanoparticle (AGuIX) for contrast enhanced MRI of the liver in a rat model of hepatic colorectal cancer metastases at 9.4 tesla
Rofo., 2015, 187, 1108-1115.
P. Fries, D. Morr, A. Müller, et al.
Gadolinium based-nanoparticles for theranostic MRI-Radiosensitization
Nanomedicine, 2015, 11, 1801-1815.
F. Lux, L. Sancey, A. Bianchi, et al.
Nanoparticules ultrafines en radiothérapie : le cas des AGuIX
Cancer Radiother., 2015, 19, 508-514.
F. Lux, A. Detappe, S. Dufort, et al.
3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography
Frontiers in Oncology, 2021, 11, 55466.
E. Longo, L. Sancey, A. Cedola, et al.
Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform
Lab on a Chip, 2021, 21, 2495-2510.
S. Goodarzi, A. Prunet, F. Rossetti, et al.
Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells
Nanomedicine, 2014, 10, 1751-1755.
M. Luchette H. Korideck, M. Makrigiorgos, et al.
Targeting and in vivo imaging of non-small-cell lung cancer using nebulized multimodal contrast agents
PNAS, 2014, 111, 9247-9252.
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Gadolinium-based nanoparticles to improve the hadrontherapy performances
Nanomedicine: NBM, 2014, 10, 1601-1608.
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Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment
Cancer Nanotechnology, 2014, 5, 4.
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Cell localisation of gadolinium-based nanoparticles and related radiosensitizing efficacy in glioblastoma cells
Cancer Nanotechnology, 2014, 5, 6.
L. Stefancikova, E. Porcel, P. Eustache, et al.
Quantitative biodistribution and pharmacokinetics of multimodal gadolinium-based nanoparticles for lungs using ultrashort TE MRI
Magn. Reson. Mater. Phy., 2014, 27, 303-316.
A. Bianchi, S. Dufort, F. Lux, et al.
Laser-induced breakdown spectroscopy: a new approach for nanoparticle’s mapping and quantification in organ tissue
J. Vis. Exp., 2014, 88, e51353
L. Sancey, V. Motto-Ros, S. Kotb, et al.
Laser spectrometry for multi-elemental imaging of biological tissues
Sci. Rep., 2014, 4, 6065.
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The issues and tentative solutions for contrast-enhanced magnetic resonance imaging at ultra-high field strength
WIREs Nanomed Nanobiotechnol, 2014, 6, 559-573.
P. Fries, J. N. Morelli, F. Lux, et al.
Small rigid platforms functionalization with quaternary ammonium : targeting extracellular matrix of chondrosarcoma
Nanomedicine :NBM, 2014, 10, 1887-1895.
E. Miot-Noirault, A. Vidal, J. Morlieras, et al.
Long distance energy transfer photosensitizers arising in hybrid nanoparticles leading to fluorescence emission and singlet oxygen luminescence quenching
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Multifunctionnal Peptide-Conjugated Hybrid Silica Nanoparticles for Photodynamic Therapy and MRI
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